Bactofos Plus 50g
Broad-Spectrum Antibiotic for Poultry and Swine
Bactofos Plus 50g is a water-soluble veterinary antibiotic formulated for the treatment of susceptible bacterial infections in poultry and swine. It combines two antibacterial active ingredients, fosfomycin and tylosin, to provide broad-spectrum activity against susceptible Gram-positive bacteria, Gram-negative bacteria and Mycoplasma organisms.
The water-soluble formulation makes Bactofos Plus 50g convenient for administration through drinking water, allowing treatment of groups of poultry or pigs without the need to dose each animal individually.
Bactofos Plus is registered in South Africa under G4325, Act 36 of 1947 and is listed by Bupo Animal Health as an antibiotic for both poultry and swine.
Key Benefits
- Broad-spectrum veterinary antibiotic
- Suitable for poultry and swine
- Contains 20% fosfomycin
- Contains 5% tylosin
- Active against susceptible Gram-positive bacteria
- Active against susceptible Gram-negative bacteria
- Active against susceptible Mycoplasma organisms
- Water-soluble powder for convenient administration
- Suitable for flock or group treatment through drinking water
- Registered veterinary medicine in South Africa
- Convenient 50g pack
Active Ingredients
| Active Ingredient | Concentration |
|---|---|
| Fosfomycin | 20% |
| Tylosin | 5% |
The combination of fosfomycin and tylosin broadens the antibacterial activity of the formulation and makes Bactofos Plus 50g suitable for a range of susceptible bacterial diseases affecting poultry and swine.
Indications
Bactofos Plus 50g is indicated for the treatment of bacterial infections caused by organisms sensitive to fosfomycin and tylosin.
Bupo Animal Health lists the following among the product’s indications:
- Mycoplasmosis
- Colibacillosis
- Chronic respiratory disease
- Coryza
- Fowl typhoid
- Avian cholera
- Listeria infections
- Staphylococcal infections
- Other susceptible bacterial infections in poultry and swine
Mycoplasmosis and Chronic Respiratory Disease
Mycoplasma organisms are an important cause of respiratory disease in poultry. Affected birds may display coughing, sneezing, nasal discharge, swollen facial areas, reduced appetite or difficulty breathing.
Bactofos Plus 50g contains tylosin together with fosfomycin and is indicated for susceptible cases of mycoplasmosis and chronic respiratory disease.
Respiratory symptoms may have several causes. Birds that are severely ill, deteriorating rapidly or failing to respond to treatment should receive appropriate veterinary assessment.
Colibacillosis
Bactofos Plus is also indicated for colibacillosis, a bacterial condition associated with pathogenic strains of Escherichia coli. Colibacillosis may occur as a primary infection or alongside respiratory and other health problems in poultry.
Correct diagnosis, hygiene, ventilation, clean drinking water and appropriate flock management remain important alongside antibiotic treatment.
Coryza, Fowl Typhoid and Avian Cholera
The registered indications for Bactofos Plus 50g also include coryza, fowl typhoid and avian cholera where the causative bacteria are sensitive to fosfomycin and tylosin.
These can be serious diseases, particularly where several birds become ill or mortality occurs. Veterinary investigation is recommended where disease spreads rapidly through a flock.
Directions for Use
Use only as directed.
Small Operations
Mix:
1g Bactofos Plus per 1 litre of drinking water.
A 50g pack will therefore prepare approximately 50 litres of medicated drinking water at this mixing rate.
Large Operations
Administer:
160mg Bactofos Plus per kg live body mass through the drinking water.
Treatment Duration
Administer Bactofos Plus 50g for 3 to 5 consecutive days.
Prepare fresh medicated drinking water daily. During treatment, the medicated water should be supplied as the drinking-water source to ensure that the animals receive the intended treatment.
Quick Mixing Guide
| Drinking Water | Bactofos Plus |
|---|---|
| 1 litre | 1g |
| 5 litres | 5g |
| 10 litres | 10g |
| 20 litres | 20g |
| 50 litres | 50g |
Withdrawal Period
Observe a 7-day withdrawal period for poultry products where applicable. Published South African veterinary guidance for Bactofos Plus lists a 7-day withdrawal period for layers and broilers.
Always comply with the withdrawal instructions printed on the current product packaging before meat or eggs from treated animals enter the human food chain.
Responsible Antibiotic Use
Bactofos Plus 50g is an antibiotic and should not be used as a routine poultry tonic or general preventative supplement.
Antibiotics are intended for bacterial infections where the causative organisms are susceptible to the active ingredients. They do not treat viral infections, nutritional deficiencies or parasite infestations.
Responsible antibiotic use helps reduce the development of antimicrobial resistance. Follow the recommended dose and treatment duration and obtain veterinary advice when animals do not respond as expected.
Important Information
- For animal use only.
- Suitable for poultry and swine.
- Use only as directed.
- Complete the recommended treatment course.
- Prepare fresh medicated drinking water daily.
- Observe the required withdrawal period.
- Keep out of reach of children and uninformed persons.
- Seek veterinary advice if animals deteriorate or fail to respond to treatment.
Product Specifications
| Feature | Details |
|---|---|
| Brand | Bupo Animal Health |
| Product | Bactofos Plus |
| Pack Size | 50g |
| Product Type | Broad-Spectrum Veterinary Antibiotic |
| Form | Water-Soluble Powder |
| Active Ingredients | Fosfomycin 20% + Tylosin 5% |
| Suitable For | Poultry & Swine |
| Small Operation Mixing Rate | 1g per 1L drinking water |
| Treatment Duration | 3–5 consecutive days |
| Registration | G4325, Act 36 of 1947 |
Bupo Animal Health lists Bactofos Plus in 25g, 50g, 100g and 1kg water-soluble powder presentations.
Why Choose Bactofos Plus 50g?
Bactofos Plus 50g combines fosfomycin and tylosin in one convenient water-soluble powder. The combination provides broad-spectrum activity against susceptible Gram-positive and Gram-negative bacteria as well as Mycoplasma organisms.
Its 50g size is particularly practical for smaller poultry and livestock operations. At the standard small-operation mixing rate of 1g per litre of drinking water, one pack prepares approximately 50 litres of medicated water.
For poultry and swine requiring treatment for susceptible bacterial infections, Bactofos Plus 50g provides a registered and convenient drinking-water treatment option.


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